D-Mannose occurs naturally in microbes, plants, animals and fruits including apples, peaches and oranges as a simple sugar. It is also found naturally in the human body. Preliminary European clinical trials have shown that D-mannose may also treat or prevent urinary tract infections (UTIs). It appears the supplement stops certain bacteria from clinging to the bladder walls. Scientists think that the bacteria stick to the sugar instead. This helps the bacteria leave the body through your urine. Fewer bacteria in the bladder lowers your risk of a urinary tract infection.
Urinary Tract Infections (UTIs)
Three clinical trials and one review has been found on D-mannose’s influence on reducing the recurrence of urinary tract infections (UTIs). The studies found consider D-mannose as an alternative therapy to antibiotic therapies. A recent review (2017) has reviewed two studies in which D-mannose was found to be a useful prophylactic therapy for recurrent UTIs. All three studies conducted in 2000s concurred on D-mannose effectiveness in preventing UTIs, while warranting further investigation to confirm the positive outcomes.
In seeking a natural remedy for reducing the use of antibiotics in urinary tract infections (UTIs), an analysis of studies was conducted on mannose’ influence on UTIs. Two studies were reviewed where D-mannose efficacy was compared to an antibiotic therapy. Even though a significant difference was not found between nitrofurantoin and D-mannose supplementation, it was noted that the antibiotic therapy led to considerable side-effects. One of the studies noted a significant decrease in UTIs recurrence in the D-mannose group in comparison with the trimethoprim/sulfamethoxazole group. The analysis concluded D-mannose’ potential in becoming a useful prophylactic therapy for recurrent UTIs. Although positive, the evidence presented is insufficient warranting further studies for the proposed alternative therapy.
Use as a Prebiotic
Some studies suggest D-mannose may play a useful role as a "prebiotic." Prebiotics are substances that may help your body by stimulating the growth of "good" bacteria in your digestive system.
In some lab studies and studies in mice, D-mannose components were shown to increase the growth of "good" bacteria. This suggests D-mannose may have some use for people with dysbiosis, an imbalance in good and bad bacteria.
Carbohydrate-Deficient Glycoprotein Syndrome (CDGS)
D-mannose is used to treat a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b. This disease is passed down through families. It makes you lose protein through the intestines. Some reports say D-mannose slows down this protein loss and makes your liver work better. It may also reduce bleeding disorders and low blood sugar in people with this disease.
D-mannose is generally safe when used in the prescribed dosages. Caution is advised during pregnancy
Other names used for D-Mannose are:
Vitalite Now D-Mannose adds Cranberry Extract as another natural supplement used against UTIs.